4 edition of The differential effects of dietary fat in a rat model of the ketogenic diet found in the catalog.
The differential effects of dietary fat in a rat model of the ketogenic diet
Cynthia A. Dell
Thesis (M.Sc.) -- University of Toronto, 2000.
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
|Pagination||2 microfiches : negative. --|
The ketogenic diet is a high-fat content diet in which carbohydrates are nearly eliminated so that the body has minimal dietary sources of glucose. Fatty acids are thus an obligatory source of cellular energy production by peripheral tissues and also the brain. With prevalence approaching one third of the population, obesity is among the most important medical problems in the United States 1 and identification of effective dietary treatment has become a major public health priority. 2 Three popular diets—low fat, low carbohydrate, and low glycemic load—have recently received much attention. However, clinical trials have produced inconsistent Cited by: The dietary modification "trick" relies upon forcing the body to convert fat to ketones. Ketones, in turn, are used by the brain as an energy source when its normal fuel, glucose, is unavailable. The ketogenic diet makes glucose unavailable to the brain by restricting access to the carbohydrate foods. Possible Side Effects of Ketogenic Diet Therapy. In mice of normal weight and with diet-induced obesity, a high-fat, low-carbohydrate ketogenic diet (KD) causes weight loss, reduced circulating glucose and lipids, and dramatic changes in hepatic gene expression. Many of the effects of KD are mediated by fibroblast growth factor 21 (FGF21).Cited by:
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THE DIFFERENTIAL EFFECTS OF DIETARY FAT IN A RAT MOOEL OF THE KETOGENIC DlET Cynthia A. Dell A thesis submitted in conforrnity with the requirements for the degree of Master of Science Graduate Department of Nutritional Sciences University of Toronto.
Recent interest in the anticonvulsant effects of acetone has stemmed from studies related to the ketogenic diet (KD). The KD, a high-fat diet used to treat drug-resistant seizures, raises blood. The ketogenic ratio is The differential effects of dietary fat in a rat model of the ketogenic diet book as the ratio of grams of fat to grams of carbohydrate plus protein.
Higher ratios result in greater degrees of ketosis. Traditionally, the KD has been calculated based on specific ratios, based on patient by: The ketogenic diet (KD) is a high-fat, low-carbohydrate, and low-protein diet that is widely used to treat epilepsy in children.
Although the KD has been shown The differential effects of dietary fat in a rat model of the ketogenic diet book be efficacious in the treatment. Rats remained on the diet throughout the testing. A plastic circular swimming pool ( cm diameter; 50 cm high) was filled to a depth of 25 cm with water.
The differential effects of dietary fat in a rat model of the ketogenic diet book total of mL of evaporated milk was added to make the water opaque and prevent visualization of the by: Dietary habits are considered to be responsible for a fatty liver.
The aims of this work are to study the effects of different lipid sources on rat hepatic structure. Twenty day-old to month-old male rats were fed one of the following diets: soybean oil, canola oil, lard and egg yolk (LE), or canola oil+lard and egg yolk (CA+LE).
The C57BL/6J mouse model is widely used for dietary studies because they are susceptible to diet-induced obesity and type 2 diabetes. A standard high-fat diet with >45 E % fat, results in weight gain and metabolic syndrome in C57BL/6J mice.
Notably, a diet that is extremely high in fat can induce a state of dietary by: The diet is high in fat and low in carbohydrate and protein, providing sufficient protein for growth but insufficient amounts of carbohydrates for all the metabolic needs of the body [ 1 ].
Energy is derived largely from fatty acid oxidation in mitochondria. During high rates of fatty acid oxidation, Cited by: High fat feeding in rodents generally leads to obesity and insulin resistance whereas in humans this is only seen if dietary carbohydrate is also high, the result of the anabolic effect of poor regulation of glucose and by: These protective effects, in addition to the reduction of oxidative stress and APP expression, may play a role in the favorable effect of ketogenic diet treatment on caspase-3 expression.
Furthermore, a plethora of evidence implicates diets high in fats and processed sugars with increased generation of free radicals in : Sahar Elsayed El-Swefy, Hebatallah Husseini Atteia.
In this regard, a rat hepatocarcinogenesis model was used to investigate the interactive effect of a toxin and dietary fats on the initiation and promotion stages of carcinogenesis (44).
The mycotoxin, fumonisin B 1 (FB 1), acts as a weak, non-genotoxic cancer initiator and expresses strong cancer promoting activity resulting in the induction Cited by: Effect of the Ketogenic Diet on the Activity Level of Wistar Rats. The ketogenic diet is a high-fat, or Prone (FAST) rat strains show differential Cited by: Introduction.
Thomas Seyfried remarked in his book [(), page 6]: “The definition of ketogenic diet allows for considerable leeway in food choices as long as the individual has reduced blood glucose and is producing ketones.”Unfortunately, these parameters are lacking in many if not most of studies into metabolic effects of by: 3.
In an animal model of cancer cachexia, administration of a low carbohydrate, high fat diet prevented weight loss of the animals while simultaneously decreasing tumor size. Similar effects were described in human cancer patients , .Cited by: Effect of the dietary fat quality on insulin sensitivity - Volume Issue 3 - José E.
Galgani, Ricardo D. Uauy, Carolina A. Aguirre, Erik O. DíazCited by: Furthermore, a low- carbohydrate diet has greater beneficial effects on glycemic control compared with a low glycemic index diet [8,15].
The KD is known to prevent the development of diabetes and reverse the damage to the pancreas in streptozotocin (STZ)- induced diabetic rat models . The ketogenic diet is a very high-fat, low-carbohydrate diet, which has a fasting-like effect bringing the body into a state of ketosis.
The presence of ketone bodies has a neuroprotective impact. The ketogenic diet (KD) is a high‐fat, low‐carbohydrate and adequate‐protein diet used to treat drug‐resistant epilepsy in children ().Clinically, 10–25% of patients with drug‐resistant epilepsy become seizure free on the KD and ∼60% experience a >50% reduction in seizure frequency (1, 2, 4, 5).Despite its anticonvulsant efficacy, the KD plays a limited role in the treatment.
A randomized study comparing the effects of a Mediterranean dietary pattern with a “prudent diet,” consisting of 50–60% carbohydrates, 15–20% protein, and total fat dietary pattern group (50/90) than in the prudent diet group (12/90) no longer had Cited by: low-carbohydrate ketogenic diets (KDs) comprise high amounts of fat with minimal carbohydrates (typically dietary lipids and adipose lipid stores for energy ().KDs were developed in the s to combat epileptic seizures ().However, many current-day research efforts have examined the effects of KDs on whole body adiposity and weight Cited by: The Ketogenic Diet is a low carbohydrate method of eating.
/r/keto is place to share thoughts, ideas, benefits, and experiences around eating within a Ketogenic lifestyle.
Helping people with diabetes, epilepsy, autoimmune disorders, acid reflux, inflammation, hormonal imbalances, and a number of other issues, every day. The overall fat content, particularly with respect to the content of saturated fats, of the habitual diet can have profound effects on lipid and lipoprotein concentrations (11, 12) and circulating levels of insulin or measures of insulin sensitivity (S I).Cited by: The aim of the current investigations was to examine the effects of a low‐carbohydrate high‐fat diet (LC‐HFD) on body weight, body composition, growth hormone (GH), IGF‐I, and body weight regain after stopping the dietary intervention and returning the diet back to standard laboratory chow (CH).Cited by: Ketogenic low-carbohydrate diets are a popular means of weight loss, and in the short-term, often result in greater weight loss than low-fat diets.
1 During fasting or restriction of dietary Cited by: A high fat (HF) diet can reduce ETC subunit formation, their assembly, and the activity of ETC complexes. 26 A discussion of the effects of dietary intake and composition of lipids on mitochondrial functions follows and is depicted in Fig. Download: Download full-size image; Fig.
The effects of a high carbohydrate diet, a high fat diet Cited by: 1. The metabolic effects of a ketogenic diet imply a higher-than-usual oxidation of fats, which leads in turn to reduced respiratory exchange ratio values.
20, Cited by: The ketogenic diet (KD) is an effective treatment against drug-resistant epilepsy in children. The KD is a diet rich in fats that produces anticonvulsant and neuroprotective effects that reduces seizures and improves the cognitive state.
Nevertheless, it can produce side effects that sometimes can be serious. Further, the effect on growth is. The closest the authors get to attacking a high-fat diet is by saying “We report a combination of molecular events in human and mouse pancreatic beta cells, induced by elevated levels of free fatty acids or by administration of a high-fat diet with associated obesity, that comprise a.
The main idea behind the ketogenic diet for fat loss is to use body fat as fuel. The goal is to eat so low carb that we force our bodies to break down our own fat in order to function.
Proponents of the ketogenic diet argue that you can lose more fat eating the same number of calories on a ketogenic diet versus a moderate or high carb diet. The ketogenic diet (KD) is a low carbohydrate, high fat diet which decreases blood glucose and elevates blood ketones and has been shown to slow cancer progression in animals and humans.
Abnormal tumor vasculature creates hypoxic pockets which promote cancer progression and further increase the glycolytic-dependency of cancers.
Adrienne Scheck, Ph.D., Senior Research Scientist at Phoenix Children’s Hospital in Phoenix, Arizona is one of the most prolific researchers when it comes to brain cancer and the ketogenic diet (AND, she is an amazing person).
As a radiation oncologist and advocate of advancing the research on the potential benefits of enhancing current treatment options with diet, I naturally came across. A new study finds that a ketogenic diet — which involves consuming high levels of fat and low levels of carbs — caused mice to live longer and grow stronger.
Adding fuel to the fire, a new study of the diet’s effects on mice showed the high fat low carb regimen increasing both strength and longevity in the rodents.
Stephanie J. Valberg, in Equine Internal Medicine (Fourth Edition), Selection of Fat Source. High-fat diets increase plasma free fatty acid concentrations and thus the availability of fats for oxidation in skeletal muscle.
98 The major sources of dietary fat for horses are vegetable-based fat, including vegetable oils and rice bran, or animal-based fat (tallow, lard, fish oil). The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children.
The diet forces the body to burn fats rather than ly, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fueling. The ketogenic diet is a high-fat content diet in which carbohydrates are nearly eliminated so that the body has minimal dietary sources of glucose.
Fatty acids are thus an obligatory source of cellular energy production by peripheral tissues and also the brain. Plasma free fatty acids are raised during ketosis. Children on the high fat ketogenic diet are usually maintained in a state of mild energy restriction, which probably contributes to the elevation in plasma free fatty acids.
We have recently reported that plasma free fatty acids are elevated 2–3 fold in children on the ketogenic diet Cited by: Dogs in nature never eat a consistently high-fat diet.
Dogs in nature don’t have access to a high-fat diet, because none of the usual prey animals in nature are fat. Think about a deer or a rabbit. There is a lot of fluff on a rabbit, but not a lot of fat. A high fat diet is not “natural” for : Demian Dressler, DVM.
No side effects or complications were observed, and the researchers stress the diet is sustainable in the long-term. They wrote: “We opine that the Paleolithic ketogenic diet ensures normal glucose levels and can be maintained on the long-term in those patients with.
DIO rats were then separated into four groups and offered for 8 weeks either: (1) the 37 % fat diet; (2) an HPLC or (3) HPMC diet; or (4) fed the 37 % fat diet to the intake of the HPMC group.
Rats offered the 37 % fat or HPLC diets gained while those on HPMC lost body fat. Blood pressure was not altered by the dietary switch. Dietary Fats Subject Areas on Research A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.
The way cancer cells utilize nutrients to support their growth and proliferation is determined by cancer cell-intrinsic and cancer cell-extrinsic Cited by: 4.Fat-burning diet can be hard to follow and hard on the environment.
Mediterranean. This top-ranked diet is healthy and eco-friendly, but consider seafood sources like fisheries and their sustainability practices to avoid overstressing the seafood supply. MIND. Dementia-prevention diet is environment-friendly – just avoid air-freighted berries.Episode 4: Dr.
Dominic D'Agostino on the Ketogenic Diet. Researcher Dr. Dominic Ebook explains the significance and best approaches to the ketogenic diet, troubleshooting common problems, and looking at the next frontier of ketogenic and fasting-related research.